| 雪腐镰刀菌烯醇致软骨细胞的损伤作用 |
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| 引用本文： | 熊咏民,曹峻岭.雪腐镰刀菌烯醇致软骨细胞的损伤作用[J].中国地方病学杂志,1994,13(5):257-260. |
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| 作者姓名： | 熊咏民 曹峻岭 |
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| 作者单位： | 西安医科大学地方性骨病研究所 |
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| 基金项目： | ＂八五＂国家重点计划攻关课题 |
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| 摘 要： | 应用不同浓度的雪腐镰刀菌烯醇（ＮＩＶ）作用于培养的兔软骨细胞，动态观察ＮＩＶ对软骨细胞生长代谢的影响。结果显示ＮＩＶ能使软骨细胞中的ＤＮＡ，基质中的葡萄糖醛酸（ＧＬｃＵＡ）和碱性磷酸酶（ＡＫＰ）含量降低。表明ＮＩＶ对软骨细胞具有明显的毒性损伤作用，能够引起软骨细胞的形态结构和代谢功能的改变。
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| 关 键 词： | 雪腐镰刀菌烯醇，软骨细胞，镰刀菌毒素，大骨节病 |
Toxic effects of nivalenol on the cultural rabbit articular chondrocytes |
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| Xiong Yongmin, Cao Junling, Zhang Shiyuan.Toxic effects of nivalenol on the cultural rabbit articular chondrocytes[J].Chinese Jouranl of Endemiology,1994,13(5):257-260. |
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| Authors: | Xiong Yongmin Cao Junling Zhang Shiyuan |
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| Abstract: | The experiment by culturing rabbit articular chondrocyte in the medium contained different nivalenol (NIV) contents was conducted to observe the effects of HIV on the growth and metabolism of the chondrocytcs in different times. The results showed that NIV could decease cellular DNA and matrix uronic acid and alkaline phosphatase contents, and morphylogical changes of the chondrocytes. Those suggested that NIV may have the significant toxic effects on thecultural rabbit articular chondrocytes. |
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| Keywords: | Nivalenol Articular chondrocyte Fusarium mycotoxins Kashin-Beck Disease |
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