| 甘草酸二铵治疗拉米夫定致HBV变异后的肝功能异常 |
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| 引用本文： | 王桂爽.甘草酸二铵治疗拉米夫定致HBV变异后的肝功能异常[J].药物不良反应杂志,2003,5(4):234-237. |
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| 作者姓名： | 王桂爽 |
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| 作者单位： | 北京地坛医院,北京,100011 |
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| 摘 要： | 目的:探讨甘草酸二铵治疗拉米夫定致HBV变异后的肝功能异常的疗效。方法:将1999年10月以来门诊使用拉米夫定治疗1年后发生病毒变异的40例患者,随机分为治疗组和对照组各20例,两组均接受一般保肝药治疗,治疗组在一般保肝治疗的基础上加用甘草酸二铵治疗,疗程8周。结果:治疗8周,肝功能恢复正常者,治疗组为15例(75%),对照组为9例(45%),治疗组疗效明显优于对照组(P<0.05)。结论:甘草酸二铵对治疗拉米夫定变异后的肝功能异常有较好的疗效。
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| 关 键 词： | 拉米夫定 HBV变异 肝功能异常 甘草酸二铵 |
Effects of diammonium glycyrrhizinate on impaired liver function associated with hepatitis B virus mutation to lamivudine |
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| Wang Guishuang.Effects of diammonium glycyrrhizinate on impaired liver function associated with hepatitis B virus mutation to lamivudine[J].Adverse Drug Reactions Journal,2003,5(4):234-237. |
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| Authors: | Wang Guishuang |
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| Abstract: | Objective:To observe diammonium glycyrrhizinate for impaired liver function due to lamivudine-induced HBV mutation.Method:40HBV-mutation cases,because of taking lamivudine for over one year,were randomly divided into treatment group and control group,20each.Two groups all received liver-protective remedies,with or without diammonium glycyrrhizinate respectively.Re sults:15cases in treatment group returned to normal liver function and only9in control group did,showing remarkable difference(P<0.05).Conclusion:Diammonium glycyrrhizinate could improve the impaired liver function in patients with lamivudine-induced HBV mutation. |
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| Keywords: | lamivudine HBVmutation impaired liver function diammonium glycyrrhizinate |
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