急性脑梗塞的动物实验及临床应用研究

目的 通过建立脑梗塞动物模型，为介入溶栓治疗提供可靠依据。方法 对10只杂种犬进行常温和加温到50度后自体血凝块注入致急性脑梗塞形成，经异管脑动脉灌注溶栓，观察血管狭窄，阻塞和再通的情况。结果 常温自体血凝块组，1－4h血管再通率为91％，6－12h溶栓占89％，12－24h溶栓为76％，总复通率占86％，加温至50度组，1－4h溶栓血管再通率为31．5％，6－12h溶栓占20％，12－24h溶栓为5％，总复通率53．6％，结论 常温自体血凝块组溶栓后血管再通率高，6h之内溶栓速度快，溶栓时间与溶栓疗效呈正相关。

Experiment Study in Animal and Clinical Application of Acute Cerebral Infarction

Purpose 　To provide information about local intra-arterial thrombolysis by establish a animal model of cerebral infarction. Methods　10 dogs were randomly divided into two groups(group A and B，n=5 for each)，group A and B were infused in self-blood clot（no-heat and heat to 50℃）respectively after selective arterio-cerebral catheterization to formal acute cerebral infarction， and local intra-arterial thrombolysis was treated before and after thrombolysis to observe the station of vessal，stenosis、occulusion and recanalization. Results　 In group A，after local intra-arterial thrombolysis at 1～4、6～12、12～24 hours， the rate of recanalization were 91%、89%、76% respectively，the total rate was 86%；In group B，the rate of recanalization were 31.5%、20%、5% respectively at same time，the total rate was 53.6%.　Conclusion 　The rate of recanalization in group A is better than group B，and the effective of local intra-arterial cerebral thrombolysis in 6 hours is better .Positive correlation was found between local intra-arterial thrombolysis time and effective.