|
|||||
|
|
Neuromuscular activity of Bothrops alcatraz snake venom in chick biventer cervicis preparations |
|
| Authors: | Delkia Seabra de MoraesValdemir Aparecido de Abreu,Sandro Rostelato-FerreiraGildo B. Leite,Maria Alice da Cruz-Hö flingSilvia R. Travaglia-Cardoso,Stephen HyslopLé a Rodrigues-Simioni |
| Affiliation: | a Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), P.O. Box 6111, 13083-970 Campinas, SP, Brazil b Department of Histology and Embryology, Institute of Biology, State University of Campinas (UNICAMP), P.O. Box 6109, 13083-970 Campinas, SP, Brazil c Herpetology Laboratory, Instituto Butantan, Avenida Vital Brazil, 1500 São Paulo, SP, Brazil d Centro Universitário Adventista (UNASP), São Paulo, SP, Brazil |
| Abstract: | Venom (10-100 μg/ml) from Bothrops alcatraz, a pitviper from the Alcatrazes Archipelago off the coast of southeastern Brazil, caused progressive, irreversible neuromuscular blockade in chick isolated biventer cervicis preparations. The venom also inhibited contractures to exogenous ACh (110 μM) and KCl (20 mM), caused myofiber damage and increased creatine kinase release. Commercial bothropic antivenom raised against mainland Bothrops species neutralized the neuromuscular activity, depending on the venom concentration. |
| Keywords: | Bothrops alcatraz Myotoxicity Neuromuscular blockade Neutralization Nicotinic receptors Snake venom |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |