Adiponectin incompletely prevent MCP-1-dependent restenosis after percutaneous coronary intervension in patients with coronary artery disease |
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Authors: | Norihito Inami Shosaku Nomura Takayuki Shimazu Kenichi Manabe Yutaka Kimura Toshiji Iwasaka |
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Institution: | (1) Second Department of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan;(2) Division of Hematology, Kishiwada City Hospital, 1001 Gakuhara-cho, Kishiwada Osaka, 596-8501, Japan |
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Abstract: | Background Some factors play pathogenic roles in the development of restenosis after percutaneous coronary intervention (PCI). We measured
and compared the ratio of elevated levels of monocytic chemotactic peptide-1 (MCP-1), regulated on activation normally T-cell
expressed and secreted (RANTES), soluble (s) P-selectin, sE-selectin and adiponectin after PCI.
Methods Plasma levels of chemokines and soluble markers were measured before and 30 days after PCI in 96 patients (69 males and 27
females, aged 63 ± 9 years) who underwent PCI and who had repeated angiograms at a 6-month follow-up. In addition, we carried
out the basic study of the tissue factor expression on monocytic cell line (THP-1) by MCP-1.
Results Restenosis occurred in 33 (34.4%) patients. A significant and time-dependent increase in MCP-1 was observed in the restenosis
group. However, there were no significant differences in RANTES, sP-selectin, and sE-selectin levels with or without restenosis.
Adiponectin levels in patients with coronary artery disease were significantly lower than levels in normal controls. However,
adiponectin levels were no different at baseline between patients with or without restenosis. MCP-1 did not induce the expression
of tissue factor on THP-1. However, the recombinant sCD40 ligand-induced expression of tissue factor on THP-1 was enhanced
by the addition of MCP-1.
Conclusion These findings suggest that restenosis development after PCI in patients with coronary artery disease may involve the participation
of MCP-1 after PCI, and adiponectin incompletely prevent this MCP-1-dependent restenosis. |
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Keywords: | Percutaneous coronary intervention Restenosis Monocyte chemotactic peptide-1 Adiponectin Coronary artery disease |
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