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电活性导电聚合物组织工程支架材料研究进展
引用本文:Li MY,Bidez P,Guterman-Tretter E,Guo Y,MacDiarmid AG,Lelkes PI,Yuan XB,Yuan XY,Sheng J,Li H,Song CX,Yen W. 电活性导电聚合物组织工程支架材料研究进展[J]. 中国医学科学院学报, 2006, 28(6): 845-848
作者姓名:Li MY  Bidez P  Guterman-Tretter E  Guo Y  MacDiarmid AG  Lelkes PI  Yuan XB  Yuan XY  Sheng J  Li H  Song CX  Yen W
作者单位:[1]School of Biomedical Engineering, Science & Health Systems, Drexel University, Philadelphia, PA 19104 [2]Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA [3]Department of Polymer Materials Science & Engineering, School of Materials Science & Engineering, Tianjin University, Tianjin 300072 [4]Tianjin Biomedical Materials Key Laboratory, Institute of Biomedical Engineering, CAMS and PUMC, Tianjin 300192
基金项目:US Army Besearch 0ffice ( YW), the Drexel & Hahnemann University Synergy Grant (YW & PIL), the Commonwealth of Pennsytvania through a grant to the Nanotechnology Institute of Southeastern Pennsylvania (YW, PIL & AGM), National Institutes of Health ( DE09848 to YW), and NASA Graduate Student Beseareh Fellowship (NAG9 - 1380)
摘    要:由于具有电活性,导电聚合物在神经和心肌等电刺激响应性细胞的培养及相关电活性组织工程支架的研究中具有潜在的应用前景,而通过键合氨基酸基团或与天然蛋白基混可以提高其生物相容性。本文主要综述两种典型的导电聚合物-聚吡咯和聚苯胺(PANi)在组织工程支架方面的研究进展,并特别阐述短肽与PANi的共价键合和电纺PANi明胶共混纳米纤维的研究。

关 键 词:导电聚合物  聚吡咯  聚苯胺  生物相容性  组织工程
文章编号:1000-503X(2006)06-0845-04
收稿时间:2006-06-14
修稿时间:2006-06-14

Research progresses on electroactive and electrically conductive polymers for tissue engineering scaffolds
Li Meng-yan,Bidez Paul,Guterman-Tretter Elizabeth,Guo Yi,MacDiarmid Alan G,Lelkes Peter I,Yuan Xu-bo,Yuan Xiao-yan,Sheng Jing,Li Hua,Song Cun-xian,Yen Wei. Research progresses on electroactive and electrically conductive polymers for tissue engineering scaffolds[J]. Acta Academiae Medicinae Sinicae, 2006, 28(6): 845-848
Authors:Li Meng-yan  Bidez Paul  Guterman-Tretter Elizabeth  Guo Yi  MacDiarmid Alan G  Lelkes Peter I  Yuan Xu-bo  Yuan Xiao-yan  Sheng Jing  Li Hua  Song Cun-xian  Yen Wei
Affiliation:1. School of Biomedical Engineering, Science & Health Systems, Drexel University, Philadelphia, PA 19104
2. Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
3. Department of Polymer Materials Science & Engineering, School of Materials Science & Engineering, Tianjin University, Tianjin 300072
4. Tianjin Biomedical Materials Key Laboratory,Institute of Biomedical Engineering, CAMS and PUMC, Tianjin 300192
Abstract:Electroactive and/or electrically conductive polymers have shown potential applications in the culture of excitable cells and as the electroactive scaffolds for neuronal or cardiac tissue engineering. The biocompatibility of the conductive polymer can be improved by covalently grafting or blending with oligo- or po- lypeptides. The new progresses in this area on two types of conductive polymers,polypyrrole and polyaniline (PANi) are reviewed in this paper. The studies of oligopeptide-modified PANi and electrospun PANi/gelatin nanofibers are highlighted.
Keywords:conductive polymer   polypyrrole   polyaniline   biocompatibility   tissue engineering
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