| 过氧化物酶体增殖物激活受体的心血管保护作用 |
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| 引用本文： | 江珊,李萍. 过氧化物酶体增殖物激活受体的心血管保护作用[J]. 中国现代医学杂志, 2012, 22(16): 58-62 |
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| 作者姓名： | 江珊 李萍 |
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| 作者单位： | 1. 辽宁省锦州市中心医院心血管内科,辽宁锦州,121001
2. 辽宁医学院研究生学院,辽宁锦州,121001 |
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| 摘 要： | 过氧化物酶体增殖物激活受体(peroxisome proliferator-activated receptor,PPAR)是核受体超家族成员之一,它不仅可以促进脂肪细胞分化,在脂质代谢中起重要作用,还具有多种有益的生理作用:参与心脏能量代谢、增加胰岛素敏感性、抑制炎症反应,改善血管内皮功能,抑制平滑肌细胞的增殖和迁移等心血管保护作用.进一步探讨PPAR对心血管疾病的保护作用,可能为噻唑烷二酮类药物治疗糖尿病心血管并发症提供新的理论基础,也可能为心血管疾病药物治疗提供新的治疗靶点.
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| 关 键 词： | 过氧化物酶体增殖物激活受体 心血管疾病 噻唑烷二酮类 |
Cardiovascular protection of peroxisome proliferator-activated receptor |
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| JIANG Shan , LI Ping. Cardiovascular protection of peroxisome proliferator-activated receptor[J]. China Journal of Modern Medicine, 2012, 22(16): 58-62 |
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| Authors: | JIANG Shan LI Ping |
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| Affiliation: | 1(1.Department of cardiovascular,Jinzhou Central Hospital,Jinzhou,Liaoning 121001,P.R.China;2.Gratuate College,Liaoning Medical University,Jinzhou,Liaoning 121001,P.R.China) |
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| Abstract: | Peroxisome proliferator-activated receptor(PPAR) was classified as orphan members of the nuclear receptor superfamily.It not only includes adipocyte differentiation and regulates the metabolism of lipids,but plays some critical biological functions.PPARs manipulate cardiac energy metabolism,enhance insulin sensitivity,downregulate inflammatory reaction,improve the endothelium function and inhibit vascular smooth muscle cells proliferation.This article reviews the relationship between PPARs and cardiovascular disease in order to provide important insight into the roles of thiazolidinediones(TZDs) in treating diabetic complication and find new targets for cardiovascular drugs in the future. |
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| Keywords: | peroxisome proliferator-activated receptors cardiovascular disease thiazolidinediones |
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