神经节苷脂治疗新生儿黄疸听力损伤的疗效观察

目的观察神经节苷脂对新生儿高未结合胆红素血症造成的脑干听力诱发电位（BAEP）异常的治疗作用。方法回顾性分析高未结合血症患儿的临床资料,并在患儿3月龄进行BAEP复检。结果对照组3月龄BAEP异常率高达53.8%,且中、重度异常率高达19.1%;治疗组3月龄BAEP异常率仅为9.64%,且以轻度异常为主,中、重度异常率仅为2.4%。治疗组3月龄BAEP异常率明显下降。各项指标差异均有统计学意义（P〈0.05）。结论对高未结合胆红素血症患儿听力损伤早期应用神经节苷脂可改善其远期听力功能障碍。

Effect of ganglioside on BAEP abnormal resulting from hyperbilirubinemia of newborns

Objective To evaluate long term effect of ganglioside on BAEP(brainsten auditory evoked potential) development in neonatal hyperbilirubinemia.Methods Newborns with BAEP abnormal were collected and checked again in 3 month age Treatment group(83 cases) were treated with ganglioside and control group(26 cases) were not treated.The results were compared between treatment group and control group.Results In treatmeat group abnormal percent was only 9.64%,whereas in control group abnormal percent was 53.8%.And in the treatment group the abnormal degree was also better than that in the control group.That makes a significantly difference(P < 0.05).Conclusion The curative effect of ganglioside treatment of the neonate patients abnormal in the BAEP resulting from hyperbilirubinemia is remarkable.