Piezoelectric guidance channels enhance regeneration in the mouse sciatic nerve after axotomy |
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Authors: | Patrick Aebischer Robert F. Valentini Paolo Dario Claudio Domenici Pierre M. Galletti |
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Abstract: | Piezoelectric nerve guidance channels made of polyvinylidene fluoride (PVDF) were evaluated in a transected mouse sciatic nerve model. Poled PVDF channels were compared to unpoled PVDF channels after 4 and 12 weeks of implantation. In all animals, the proximal and distal nerve stumps were bridged by a continuous nerve cable. Nerves regenerated in poled channels contained a higher number of myelinated axons than those regenerated in unpoled channels at both time periods. We conclude that piezoelectric nerve guidance channels enhance peripheral nerve regeneration and provide a tool to investigate the influence of electrical activity on nerve regeneration. |
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Keywords: | Guidance channel Axonal regeneration Nerve transection Piezoelectric tube |
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