Negative chronotropic effect of cannabinoids and their water-soluble emulsion is related to activation of cardiac CB1 receptors |
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| Authors: | A V Krylatov L N Maslov S Yu Ermakov E I Barzakh O V Lasukova D Crawford R Ghadessy V Yu Serebrov |
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| Institution: | (1) Institute of Cardiology, Siberian Division of Russian Academy of Medical Sciences, Tomsk;(2) Tomsk State Pedagogical University, Russia;(3) Siberian State Medical University, Tomsk;(4) Tocris Cookson, Bristol, UK |
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| Abstract: | Intravenous injection of cannabinoids dissolved in cremophore EL:ethanol:NaCl mixture and water-soluble emulsion of the same
cannabinoids caused identical negative chronotropic effects in chloralose-narcotized rats. Selective CB1 and CB2 receptor
antagonist HU-210 also induced a negative chronotropic effect in rats, while pre-injection of CB1 receptor antagonist SR 141716A
completely abolished this effect of HU-210. Selective CB2 receptor antagonist SR 144528 had no effect on HU-210-induced bradycardia.
Preinjection of ganglioblocker hexamethonium also did not abolish the negative chronotropic effect of HU-210 and ACPA. Perfusion
of isolated rat heart with Krebs-Henseleit solution containing HU-210 in a final concentration of 100 nM reduced heart rate.
It was shown that the negative chronotropic effect of cannabinoids is mediated through activation of cardiac CB1 receptors.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 10, pp. 433–436, October, 2006 |
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| Keywords: | cannabinoids heart rhythm |
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