中药"长骨液"对骨延长区微量元素影响的实验研究

为了探讨中药“长骨液”对骨延长区成骨作用的影响,选用１２只２岁～３岁健康青山羊制作标准骨延长模型,随机分为对照组和实验组。实验组于术后第２天开始每天灌服“长骨液”１次（１０ｍｌ／ｋｇ）,对照组灌服等量的生理盐水。观察骨延长区成骨情况,测定延长区新骨微量元素。结果表明,实验组新骨形成与成熟均较对照组提前,且在延长区新骨中微量元素含量较对照组高。认为,“长骨液”促进骨延长区微量元素的聚集,可能是其加速骨延长区新骨形成与成熟的作用机理之一。

EXPERIMENTAL STUDY ON THE EFFECT OF CHINESE TRADITIONAL MEDICINE "BONE GROWTH FLUID" IN THE CHANGE OF TRACE ELEMENTS IN BONE LENGTHENING AREA

In order to study the effect of Chinese traditional medicine, "Bone Growth Fluid", on bone formation in bone lengthening, the limb lengthening model was made on goat to observe bone formation in the distracted area, and the content of the trace elements was determined. The bone-lengthening operation was carried out on the upper metaphysis of left tibia. The animals were divided into two groups following operation. From 2nd day afteroperation, "Bone Growth Fluid", 10 ml per kilogram body weight, was given daily to goats in the experimental group, and same amount of normal saline was given to goats in another group as control. The results showed-that new bone formation and bone remodeling in the experimental group appeared earlier than that in the control group, and the content of the trace elements was also improved. So Chinese Traditional medicine, "Bone Growth Fluid", could accelerate the accumulation of the trace elements in callus on the distracted sites and it might play some role in the promotion of osteogenesis and bone remodeling in bone lengthening.