| 脂蛋白(a)与心血管疾病的关系 |
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| 引用本文： | 韩爱忠,汪俊军. 脂蛋白(a)与心血管疾病的关系[J]. 临床心血管病杂志, 2012, 0(9): 643-645 |
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| 作者姓名： | 韩爱忠 汪俊军 |
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| 作者单位： | 济宁医学院生物科学系;南京军区南京总医院全军临床检验医学研究所 |
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| 基金项目： | 国家自然科学基金资助项目(No:30872411) |
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| 摘 要： | 脂蛋白(a)[Lp(a)]结构类似于低密度脂蛋白(LDL),高水平Lp(a)是一种公认的心血管疾病危险因子。体内存在氧化型Lp(a)更易于促进动脉粥样硬化的发生发展。Lp(a)中的载脂蛋白(a)[apo(a)]存在异质性,研究显示其危险性可能是由于apo(a)等位基因水平差异引起的,而且apo(a)的多态性影响到Lp(a)水平的临床测定,如何降低apo(a)对结果的影响还需要更多深入研究。目前针对高Lp(a)水平的人群尚无统一的治疗标准,但降脂治疗有益于预防心脑血管疾病的发生。
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| 关 键 词： | 脂蛋白(a) 载脂蛋白(a) 动脉粥样硬化 危险因子 |
Lipoprotein(a) and cardiovascular diseases |
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| HAN Aizhong,WANG Junjun. Lipoprotein(a) and cardiovascular diseases[J]. Journal of Clinical Cardiology, 2012, 0(9): 643-645 |
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| Authors: | HAN Aizhong WANG Junjun |
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| Affiliation: | 1Department of Biological Sciences,Jining Medical University,Rizhao,Shandong,276826,China;2Institute of Laboratory Medicine Science of People’s Liberation Army,Nanjing General Army Hospital) |
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| Abstract: | Lipoprotein(a) is an atherogenic particle which structurally resembles low density lipoprotein.Elevated plasma concentrations of Lp(a) is an independent risk factor for atherosclerosis.Ox-Lp(a) has been reported to play a more potent role than native Lp(a) in atherosclerosis.Apolipoprotein(a) is heterogeneous,and the risk of Lp(a) may be due to the differences of apolipoprotein(a) allele level.The polymorphism of apolipoprotein(a) affects clinical determination of Lp(a) level.How to reduce the influence of heterogeneity still need more research.At present,there is no uniform standard treatment for the people with high Lp(a) level,but lipid-lowering therapy can prevent cardiovascular diseases. |
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| Keywords: | Lipoprotein(a) apoprotein(a) atherosclerosis risk factor |
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