支气管动脉灌注化疗药物治疗局部晚期非小细胞肺癌

目的：观察支气管动脉灌注化疗药物治疗局部晚期非小细胞肺癌的疗效。方法：1992年6月－1998年10月102例局部晚期非小细胞肺癌进入该研究。Ⅱ期8例，Ⅲa期72例，Ⅲb22例，中央型75例，周围型27例，初治组64例，复治组38例，采用支气管动脉灌注顺铂加长春花碱酰胺或者丝裂霉素加阿霉素加顺铂。结果：完全缓解3例，部分缓解66例，总有效率为67．65％（69／102），中央型为72．00％（54／75），周围型55．56％（15／27），1－2年生存率为67．64％（69／102）和36．28％（37／102），结论：支气管动脉灌注化疗药物治疗局部晚期非小细胞胞癌疗效较高，毒副作用少，且对中央肺癌的疗效优于周围型肺癌。

Bronchial Arterial Infusion of Chemotherapeutic Drugs in Treatment of Patients with Locally Advanced Non-Small Cell Lung Cancer

Objective: This study was designed to evaluate the therapeutic efficacy of bronchial arterial infusion with VDS＋ DDP or MMIC＋ ADM＋ DDP in patients with locally advanced nonsmall cell lung cancer(NSCLC). Methods: From June 1992 to October 1998,102 patients with locally advanced NSCLC were enrolled in this study. Of them,8 cases in Stage Ⅱ , 72 cases in Stage Ⅲ a, 22 cases in Stage Ⅲ b, central type: 75 cases,peripheral type:27 cases;preliminary group 64 cases, secondary group 38cases. The patients were treated one to four times by bronchial arterial infusion of the chemical drugs Results: There were 3 complete responses and 66 partial responses for an overall responses rate of 67.65％ (69/102) including responses rate of 72.00％ (54/75) in central type and 55.56％ (15/27), the 1-year and 2-years survival rate was 67.64％ (69/102)and 36.28％ (37/102) respectively. Conclusions: The therapeutic efficacy of bronchial arterial infusion with chemical drugs was excellent to locally advanced non small cell lung cancer, it′ s toxicity were acceptable. The efficacy on central was much better than for peripheral type