| 抗精神病药阿立哌唑的合成工艺改进 |
| |
| 引用本文： | 葛海霞,王礼琛,倪生良. 抗精神病药阿立哌唑的合成工艺改进[J]. 中国现代应用药学, 2007, 24(4): 294-295 |
| |
| 作者姓名： | 葛海霞 王礼琛 倪生良 |
| |
| 作者单位： | 1. 湖州师范学院,浙江,湖州,313000
2. 中国药科大学有机化学教研室,南京,210009 |
| |
| 摘 要： | 目的改进抗精神病药阿立哌唑的合成工艺。方法以间氨基苯甲醚为原料,经酰胺化、傅-克烃化、醚化、N-烷基化四步反应合成阿立哌唑。结果通过优化条件合成了阿立哌唑,总收率40%,目标化合物的结构经元素分析、质谱、氢谱、红外光谱确证。结论改进后的工艺操作简便,易于控制,且节省了反应时间,降低了生产成本,更有利于工业化生产。
|
| 关 键 词： | 阿立哌唑 合成 工艺改进 抗精神病药 |
| 文章编号： | 1007-7693（2007）04-0294-02 |
| 修稿时间： | 2006-12-12 |
Improved Synthesis of Antipsychotic Drug Aripiprazole |
| |
| GE Hai-xi,WANG Li-chen,NI Sheng-liang. Improved Synthesis of Antipsychotic Drug Aripiprazole[J]. The Chinese Journal of Modern Applied Pharmacy, 2007, 24(4): 294-295 |
| |
| Authors: | GE Hai-xi WANG Li-chen NI Sheng-liang |
| |
| Affiliation: | 1. Huzhou Teachers College, Huzhou 313000, China; 2. Department of Organic Chemistry, China Pharmaceutical University ,Nanjing 210009, China |
| |
| Abstract: | OBJECTIVE To improve the synthetic procedure of antipsychotic drug aripip-razole.METHODS Aripiprazole was synthesized via four steps starting from m-Anisidine. RESULTS Aripiprazole was prepared in an overall yield of 40%.The structure of the target compound was confirmed by MS,1H-NMR,IR spectra and elemental analysis.CONCLUSION The method is suitable for industrial manufacture. |
| |
| Keywords: | aripiprazole synthesis process improvement antipsychotic |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《中国现代应用药学》浏览原始摘要信息 |
|
点击此处可从《中国现代应用药学》下载全文 |
|
