| 通脉活血灵胶囊对血小板聚集功能的影响 |
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| 引用本文： | 李兰芳,李永辉,张建新,许贵新.通脉活血灵胶囊对血小板聚集功能的影响[J].河北中医,2006,28(12):943-945. |
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| 作者姓名： | 李兰芳 李永辉 张建新 许贵新 |
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| 作者单位： | 河北省医学科学院,石家庄,050021;河北省食品药品监督管理局稽查处,石家庄,050091 |
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| 摘 要： | 目的观察通脉活血灵胶囊对血小板聚集功能的影响。方法将不同浓度的通脉活血灵胶囊提取液分别加入大鼠、豚鼠和家兔含有一定数量血小板的血浆液中,用二磷酸腺苷(ADP)诱导聚集,用比浊法测定血小板聚集率;将不同剂量的通脉活血灵胶囊提取液给豚鼠灌胃,分别制备含药血小板血浆,加入诱导剂ADP,观察豚鼠口服药物后对血小板聚集功能的影响。结果通脉活血灵胶囊提取液10.0%、5.0%、2.5%对大鼠和家兔,5.0%、2.5%对豚鼠的血小板聚集均有非常明显的抑制作用。大鼠口服通脉活血灵胶囊提取液后制备的含药血浆对诱导剂ADP引起的血小板聚集亦有明显的抑制作用。结论大鼠、豚鼠和家兔血浆的体外和豚鼠体内实验均证明通脉活血灵胶囊具有抑制血小板聚集的功能。
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| 关 键 词： | 通脉活血灵胶囊 血小板聚集 |
| 文章编号： | 1002-2619（2006）12-943-03 |
| 收稿时间： | 2006-10-16 |
| 修稿时间： | 2006-10-16 |
Effects of Tongmaihuoxueling capsule on platelet aggregation |
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| LI Lanfang , LI Yonghui , ZHANG Jianxin ,et al..Effects of Tongmaihuoxueling capsule on platelet aggregation[J].Hebei Journal of Traditional Chinese Medicine,2006,28(12):943-945. |
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| Authors: | LI Lanfang LI Yonghui ZHANG Jianxin |
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| Institution: | Hebei Academy of Medical Sciences, Shijiazhuang 050021 |
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| Abstract: | Objective To observe the effects of Tongmaihuoxueling capsule(TMHXLC) on platelet aggregation.Methods Arterial blood samples were respectively from rat,guinea pig and rabbit(normal animals) and from the guinea pig that TMHXLC were administrated for three days,and then the platelet rich plasmas(PRP) were respectively prepared.After separate addition of different concentrations of TMHXLC to the PRP,the ADP-induced platelet aggregation was respectively measured by turbidimetric method. Results The ADP-induced platelet aggregating action was significantly decreased by different concentrations of TMHXLC,and so did in PRP from TMHXLC treated animals.Conclusion It could be concluded that TMHXLC has anti platelet aggregating action in vivo and in vitro. |
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| Keywords: | Tongmaihuoxueling Capsule Platelet aggregation ADP |
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