Recurrent rhabdomyolysis and myoglobinuric acute renal failure in a patient with polymyositis. |
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| Authors: | Hyung Wook Kim Joung Ran Choi See Jin Jang Yoon Sik Chang Byung Kee Bang Cheol Whee Park |
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| Institution: | Division of Nephrology, Department of Internal Medicine, St Vincent's Hospital, The Catholic University of Korea, 93 Chi-Dong, Paldal-Ku, Suwon 442-723 Korea. |
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| Abstract: | |
Introduction
| We report on a 57-year-old woman with polymyositis who on twooccasions presented with rhabdomyolysis and myoglobinuria, withresultant oliguric acute renal failures, the second episosdeof which required haemodialysis. Polymyositis is a rare and gradually progressive autoimmuneinflammatory disease of skeletal muscle that is characterizedby muscle weakness, usually proximal and symmetric, elevatedmuscle enzymes, and distinctive findings on electromyographyand muscle biopsy 1]. The disease may be associated with infectionsor with other collagen vascular diseases, such as Sjögren'ssyndrome and sarcoidosis 1]. Rhabdomyolysis is a term that refers to disintegration of striatedmuscle, which results in the release of muscle cell constituents,in particular myoglobin, into extracelluar fluid and the circulation.The released myoglobin is filtered by glomeruli and reachesthe tubules, where it may cause obstruction and renal dysfunction2]. The main causes of rhabdomyolysis
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| Keywords: | acute renal failure myoglobin polymyositis rhabdomyolysis |
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