Effects of sex hormones and antihormones on the activity of redox system enzymes of human erythrocyte glutathione |
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| Authors: | P V Sergeev S A Chukaev Yu A Korovkina |
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| Institution: | (1) Department of Molecular Pharmacology and Radiobiology, Russian State Medical University, Moscow |
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| Abstract: | Effects of estradiol and testosterone and of the antiandrogens cyproterone acetate, niftolide, and antiestrogen tamoxifen
on the activities of human erythrocyte glutathione peroxidase and glutathione reductase were studiedin vitro. In contrast to hormone preperations, antihormones in high concentrations (10−4−5×10−4 M) modified the enzyme activities. Cyproterone acetate and tamoxifen increased the activity of glutathione reductase, while
tamoxifen stimulated glutathione reductase and inhibited glutathione peroxidase. Niftolide inhibited both enzymes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 8, pp. 185–187, August, 1997 |
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| Keywords: | glutathione peroxidase glutathione reductase sex hormones antihormones erythrocytes |
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