The usefulness and limitations of CEA assay in the management of colorectal cancer |
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Authors: | Hirotsugu Tomoda Motonosuke Furusawa |
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Institution: | (1) Department of Surgery, National Kyushu Cancer Center, 815 Fukuoka, Japan |
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Abstract: | We investigated the usefulness and limitations of the measurement of CEA in the evaluation of tumor resection and the detection
of recurrence in colorectal cancer patients. Preoperatively, 46 of 90 patients (51.1%) had CEA values of 5.0 ng/ml or higher.
The percentage of patients with elevated CEA in whom the CEA values returned to normal one month postoperatively was significantly
higher in those who had undergone a curative resection than in those who had undergone a non-curative resection (p<0.02).
Among patients with normal CEA values, the changes were nil or only slight in CEA values, one month postoperatively
Among 28 with recurrences, 24 (85.7%) had CEA values of 5.0 ng/ml or higher. All 11 with liver recurrences had values of 10.0
ng/ml or higher. In 4 with liver recurrences and in cases where CEA measurements were made, CEA values were found to be abnormal
3 to 10 months before the recurrences and a rapid elvation occurred for a short period. However, 4 out of 10 with local or
lymphnode recurrences showed normal CEA values. CEA measurement was useful in detection of liver recurrences, but not so useful
in detecting local or lymphnode recurrences. |
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Keywords: | carcinoembryonic antigen (CEA) colorectal cancer tumor resection recurrence |
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