Computer-Assisted Continuous Infusion for the Delivery of Target-Controlled Infusions of Propofol During Outpatient Surgery |
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| Authors: | Dr George A Arndt MD Dr William G Reiss PharmD Kris A Bathke PharmD Dr Scott R Springman MD Dr Gavin Kenny MD |
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| Institution: | 1. School of Pharmacy, University of Maryland, Baltimore, Maryland;2. Department of Anesthesiology, University of Wisconsin Medical School, Madison Wisconsin;3. University Department of Anesthesia, Glasgow Royal Infirmary, Glasgow, Scotland |
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| Abstract: | Propofol was administered intravenously using a first-order, three-compartment, computer-controlled infusion pump (CCIP) based on the Ohmeda 9000 syringe pump. The CCIP system produced a target-controlled infusion (TCI) based on the estimated blood concentration (EBC). Twenty-five patients undergoing ambulatory surgery completed the study. The induction EBC was 4.72 ± 0.28 μg/ml, and was achieved rapidly with minimal hemodynamic changes. The emergence EBC was 1.55 ± 0.21 μg/ml, and the discharge EBC was 1.06 ± 0.22 μg/ml. The EBC, together with clinical signs, allowed for predictable inductance and emergence from anesthesia using propofol. |
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