A Double-Blind Study Comparing Two Single-Dose Regimens of Ketorolac with Diclofenac in Pain Due to Cancer |
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| Authors: | Vincenzo Minotti M.D. Maura Betti M.D. Gianni Ciccarese M.D. Guglielmo Fumi M.D. Maurizio Tonato M.D. Albano Del Favero M.D. |
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| Affiliation: | Division of Medical Oncology (Drs. Minotti, Betti, Ciccarese, and Tonato), and the Institute of Internal Medicine (Drs. Fumi and Del Favero), Perugia Hospital, Perugia, Italy. |
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| Abstract: | Study Objective . To compare the analgesic efficacy and safety of two single doses of ketorolac with diclofenac in acute cancer pain. Design . Double-blind, randomized, clinical study. Setting . Hospital-based clinical research center. Subjects . One hundred eighty patients suffering acute, moderate, or severe cancer pain. Interventions . A single intramuscular injection of ketorolac 10 or 30 mg or diclofenac 75 mg. Measurements and Main Results . Pain intensity was assessed 30 minutes and 1, 2, 3, 4, 5, and 6 hours after injection or until rescue drug administration. In approximately 70% of patients all treatments provided prompt sustained pain relief throughout the 6-hour observation period. There were no statistically significant differences in any of the analyzed efficacy measures among the three groups. Conclusion . Intramuscular ketorolac 10 mg is adequate to relieve cancer pain, and is equivalent to ketorolac 30 mg and to diclofenac 75 mg. |
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