Flucytosine Dosing in an Obese Patient With Extrameningeal Cryptococcal Infection |
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| Authors: | Dr. J. Gregory Gillum Pharm. D. Dr. Mark Johnson Pharm. D. Dr. Suzanne Lavoie M.D. Dr. Jurgen Venitz M.D. Ph.D. |
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| Affiliation: | 1. Department of Pharmacy and Pharmaceutics, School of Pharmacy, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia;2. Division of Infectious Diseases, Department of Medicine and Pediatrics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia |
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| Abstract: | A 31-year-old, obese woman with extrameningeal cryptococcal disease was admitted to the Medical College of Virginia for antifungal therapy. Various physiologic variables influence flucytosine pharmacokinetics, and there are no guidelines for dosing the agent in obese patients. This patient received a dosage based on her ideal body weight, and serum drug concentrations were monitored. She recovered without sequelae. |
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