ACUTE PSYCHOSIS ASSOCIATED WITH ABRUPT WITHDRAWAL OF CARBAMAZEPINE FOLLOWING INTOXICATION |
| |
| Authors: | D Darbar MB ChB AM Connachie AM Jones MRCPsych RW Newton FRCP(E) |
| |
| Affiliation: | 1. Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland;2. Department of Pharmacy, Ninewells Hospital and Medical School, Dundee, Scotland;3. Department of Psychiatry, Ninewells Hospital and Medical School, Dundee, Scotland |
| |
| Abstract: | SUMMARY Carbamazepine is regularly used in the treatment of trigeminal neuralgia. Although exacerbation of psychosis has been described following abrupt discontinuation of carbamazepine in chronic schizophrenics, a withdrawal syndrome has not been reported previously in patients treated for trigeminal neuralgia. The case presented here suggests that abrupt withdrawal of toxic concentrations of carbamazepine may precipitate a withdrawal reaction, which is manifest some days after discontinuation of the drug. Therefore it may be advisable to withdraw therapy slowly in these situations. |
| |
| Keywords: | |
|
|
