Sarcoidosis in chronic granulomatous disease |
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Authors: | De Ravin Suk See Naumann Nora Robinson Michael R Barron Karyl S Kleiner David E Ulrick Jean Friend Julia Anderson Victoria L Darnell Dirk Kang Elizabeth M Malech Harry L |
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Affiliation: | National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. |
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Abstract: | In addition to increased susceptibility to infections in patients with chronic granulomatous disease (CGD), a higher incidence of sterile inflammatory disorders in these patients has been noted. However, sarcoidosis has not been reported previously in CGD. In this report, we describe two patients who have CGD and a disorder consistent with sarcoidosis on the basis of unequivocal clinical-radiographic presentations, their responses to treatment, and serum angiotensin-converting enzyme levels. Serum angiotensin-converting enzyme levels were measured in 26 other patients with CGD to establish an appropriate reference range. A possible relationship between CGD and sarcoidosis is discussed. |
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