血液感染常见病原真菌分布及耐药性分析

目的了解真菌性血液感染常见病原真菌的菌群分布及耐药性状况,为临床诊治提供依据。方法用WHONET5统计软件回顾性分析2004-2006年导致真菌性血液感染的病原真菌的菌群分布及药物敏感性状况。结果从血液标本共分离出94株病原真菌,其中白色念珠菌、热带念珠菌、光滑念珠菌、近平滑念珠菌的分离率分别为25.5%,22.1%,19.1%,19.1%。4种主要念珠菌对两性霉素B及5-氟胞嘧啶的总的敏感性最高分别为96.8%,100%,对氟康唑的总的敏感率为87.2%,对伊曲康唑的总的敏感率最低仅为51.1%。结论应重视对血液真菌感染患者的检测及合理用药以有效控制病情。

Distribution and drug resistance of pathogenic fungi common seen in blood infection

Objective To investigate the distribution and drug resistance analysis of pathogenic fungi isolated from blood specimens of blood stream infection. Methods A restrospective study from 2004 to 2006 year was made with WHONET 5 software. Results Totally 94 strains of pathogenic fungi were isolated and isolate rates of the Candida albicans, Candida tropicalis, Candida glabrata, Candida parapsilosis were 25.5%,22.1%,19.1%,19.1% respectively, susceptibility for Flucytosin, Amphotericin B, was 96.8%,100%,and Fluconzazole was 87.2%, and Itraconazole was more lower (51.1%). Conclusion Fungus be detected and drug sensitivity tests be conducte to provide reference for guiding clinical reasonable choice of drugs.