Screening for prostate cancer using prostate-specific antigen testing in Japanese men on hemodialysis |
| |
Authors: | Toshifumi Kurahashi Hideaki Miyake Masashi Shinozaki Nobutoshi Oka Atsushi Takenaka Isao Hara Yosuke Matsumura Masato Fujisawa |
| |
Institution: | (1) Division of Urology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan;(2) Department of Urology, Hara Genitourinary Hospital, Kobe, Japan;(3) Hyogo Health Service Association, Kobe, Japan |
| |
Abstract: | Objectives The objectives of this study were to evaluate the usefulness of serum prostate-specific antigen (PSA) screening in detecting
prostate cancer in Japanese men on hemodialysis, and to analyze features of prostate cancer detected in these patients.
Materials and methods This study included 115 male hemodialysis patients aged >55 years who agreed to the measurement of serum PSA value (group
A) and 7529 men aged >55 years participating in a PSA mass screening test in Kobe City (group B) between April 2005 and March
2006. Prostate biopsy was recommended in men with serum PSA > 4.0 ng/ml in both groups. Seventy-eight patients with normal
renal function aged >55 years diagnosed as having prostate cancer during the same time period as groups A and B were also
included as a comparison group (group C).
Results There was no significant difference in the distribution of serum PSA values between groups A and B. Prostate biopsy was performed
in 8 and 205 men in groups A and B, respectively, and prostate cancer was detected in 5 and 68 in groups A and B, respectively;
that is, there was no significant difference in the rate of positive prostate biopsy between these two groups (group A, 62.5%;
group B, 33.2%), while the cancer detection rate in group A (4.3%) was significantly greater than that in group B (0.90%).
In addition, there was no evident metastasis in five patients on hemodialysis who were diagnosed as having prostate cancer,
and their serum PSA, clinical T stage and biopsy Gleason score were similar to those in group C. However, the percent of positive
biopsy cores in these five was significantly greater than that in group C. All five were treated by maximal androgen blockade
therapy, and all are currently alive without emergence of hormone-refractory diseases.
Conclusions These findings indicate that hemodialysis patients may have an increased risk of prostate cancer, and that prostate cancer
detected in such patients tends to be relatively advanced. Therefore, it would be recommended for hemodialysis patients to
undergo PSA testing to screen for prostate cancer. |
| |
Keywords: | Hemodialysis Prostate cancer Prostate-specific antigen Screening |
本文献已被 PubMed SpringerLink 等数据库收录! |
|