左旋门冬氨酸-鸟氨酸治疗肝硬化合并肝性脑病疗效观察

目的 观察左旋门冬氨酸-鸟氨酸治疗肝硬化合并肝性脑病的临床疗效。方法 将85例肝硬化并肝性脑病患者随机分为治疗组(40例)和对照组(45例)。治疗组在常规综合治疗的基础上将左旋门冬氨酸-鸟氨酸40ml加入10%葡萄糖盐水250ml中静脉滴注,1次/d,7d为1疗程。结果 左旋门冬氨酸-鸟氨酸可明显降低血氨和改善肝功能(P<0.05或0.01),治疗肝性脑病临床疗效显著优于对照组(P<0.05),且无明显不良反应。结论 左旋门冬氨酸-鸟氨酸是治疗肝性脑病有效药物,无明显不良反应,有临床推广应用价值。

Therapeutic effect of L-ornithine-L-aspartate on liver cirrhosis complicated by hepatic encephalopathy

Objective To observe the therapeutic effects of L-ornithine-L-aspartate on liver cirrhosis complicated by hepatic encephalopathy. Methods Eighty-five patient with liver cirrhosis complicated by hepatic encephalopathy were divided into therapy group (n=45) and control group (n=40). Patients in the control group were treated with routine comprehensive therapy, and those in the therapy group received additional intravenous administration with 40 ml L-ornithine-L-aspartate in 250 ml 10% glucose and saline (once daily, 7 days for a treatment course). Results L-ornithine-L-aspartase significantly decreased blood ammonia and improved hepatic function (P<0.05 or 0.01). The therapeutic effects of therapy group was better than that of the control group (P<0.05), and no significant side effect was observed in L-ornithine-L-aspartate treatment. Conclusion L-ornithine-L-aspartate is effective for hepatic encephalopathy and has not obvious side effect.