| 多发性肌炎和皮肌炎患者外周血单一核细胞Fas、FasL和bcl-2分子的表达 |
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| 引用本文： | 张士发,许静,梁再赋,赵丽萍,王良明,刘宝军,顾绍裘.多发性肌炎和皮肌炎患者外周血单一核细胞Fas、FasL和bcl-2分子的表达[J].中国麻风皮肤病杂志,2004,20(1):4-5. |
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| 作者姓名： | 张士发 许静 梁再赋 赵丽萍 王良明 刘宝军 顾绍裘 |
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| 作者单位： | 1. 沈阳军区总医院皮肤科,沈阳,110016
2. 中国医科大学,沈阳 |
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| 摘 要： | 目的：探讨多发性肌炎(PM)／皮肌炎(DM)的外周血单一核细胞(PHMC)活化和凋亡的状态。方法：采用免疫细胞化学方法对PM／DM患者的PBMC上凋亡相关分子Fas、FasL和bcl—2等的表达进行了检测。结果：PM／DM患者PBMC上Fas、FasL和bcl—2分子的表达显著高于正常对照组。结论：PM／DM患者的PBMC存在异常活化和凋亡，与PM／DM的免疫学病理过程有关。
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| 关 键 词： | 多发性肌炎 皮肌炎 外周血 单一核细胞 Fas FasL bcl-2 细胞凋亡 |
| 修稿时间： | 2003年2月8日 |
Expressions of Fas, FasL and bcl- 2 on peripheral blood mononuclear cells in patients with polymyositis and dermatomyositis |
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| Zhang Shifa,Xu Jing,Liang Zaifu,et al..Expressions of Fas, FasL and bcl- 2 on peripheral blood mononuclear cells in patients with polymyositis and dermatomyositis[J].China Journal of Leprosy and Skin Diseases,2004,20(1):4-5. |
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| Authors: | Zhang Shifa Xu Jing Liang Zaifu |
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| Institution: | Zhang Shifa,Xu Jing,Liang Zaifu,et al. Department of Dermatology,General Hospital of Shenyang Military Region,Shenyang 110016,China |
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| Abstract: | Objective: To investigate the status of activation and apoptosis of peripheral blood mononuclear cells (PBMC) in patients with polymyositis (PM) and dermatomyositis (DM). Methods: The expression of Fas, FasL and bcl-2 associated with apoptosis molecules on PBMC was measured with immunocytochemical method in patients with PM and DM. Results: The expression of Fas,FasL and bcl-2 on PBMC in patients with PM and DM was significantly higher than that in normal controls. Conclusion:There are abnormal activation and apoptosis of PBMC in patients with PM and DM, which is associated with immunopathogenic process. |
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| Keywords: | polymyositis dermatomyositis peripheral blood mononuclear cells apoptosis |
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