长链非编码RNA与眼部增生性疾病

眼部增生性疾病,如增生性玻璃体视网膜病变(PVR)、糖尿病视网膜病变(DR)、脉络膜新生血管、角膜新生血管等常导致眼结构和功能的损伤,晚期治疗效果差.长链非编码RNA(lncRNA)是一类长度大于200个核苷酸的RNA转录本,虽不能直接编码蛋白质但可通过各种途径调节蛋白编码基因的表达,从而广泛参与调控个体的生长发育以及细胞凋亡、增生、分化等生命活动.越来越多的证据表明lncRNA参与多种眼部疾病的发生和发展,并有望成为其诊断和治疗的新靶点.本文就lncRNA的概念、分类、作用机制及其与PVR、DR、脉络膜新生血管、角膜新生血管的研究进展进行综述.

Research progress of long noncoding RNAs in ocular proliferative diseases

Ocular proliferative diseases,such as proliferative vitreous retinopathy (PVR),diabetic retinopathy (DR),choroidal neovascularization,corneal neovascularization and so on,often do harm to the structure and function of the eyes,and responses to treatments of late stage of these diseases are poor.Long noncoding RNAs (lncRNAs) with a length greater than 200 nucleotides can not directly encode a protein but can regulate the expression of protein coding genes through various pathways,and are widely involved in the regulation of body growth,as well as in cell apoptosis,proliferation and differentiation.More and more evidence suggests that lncRNAs are involved in the occurrence and development of a variety of ocular diseases.In the present paper,the concept,classification and mechanism of lncRNAs,and recent advances in the role of lncRNAs in PVR,DR,choroidal neovascularization and corneal neovascularization were reviewed.