Notch signaling: Emerging molecular targets for cancer therapy |
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Authors: | Ling Yin Zhao-Jun Liu |
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Affiliation: | a Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, United States b Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, United States |
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Abstract: | The Notch signaling pathway is a highly conserved developmental pathway, which plays a critical role in cell-fate decision, tissue patterning and morphogenesis. There is increasing evidence that this pathway is dysregulated in a variety of malignancies, and can behave as either an oncogene or a tumor suppressor depending upon cell context. This review highlights the current evidence for aberration of the Notch signaling pathway in a wide range of tumors from hematological cancers, such as leukemia and lymphoma through to skin, breast, lung, pancreas, colon and brain tumors. It proposes that the Notch signaling pathway may represent novel therapeutic targets and will be a welcome asset to the cancer therapeutic arena. |
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Keywords: | ACL, adenocarcinoma of the lung ADAM, a disintegrin and metalloprotease AML, acute myeloid leukemia APP, amyloid precursor protein B-CLL, B-chronic lymphocytic leukemia c-IAP2, cellular inhibitor of apoptosis protein 2 CSC, cancer stem cell DBZ, dibenzazepine DN-MAML1, dominant negative-mastermind-like 1 GBM, glioblastoma GIT, gastrointestinal tract GSI, γ-secretase inhibitor HD, heterodimerization hEGFRs, human epidermal growth factor receptors Herp, Hes-related repressor protein Hes, Hairy and E (spl) HIF, hypoxia-inducible-factor LNX, ligand of Numb-protein X MB, medulloblastoma MMTV, mouse mammary tumor virus NICD, Notch intracellular domain NSCLC, non-small cell lung cancers O-Fut, O-fucosyl transferase PcG, polycomb group PDAC, pancreatic ductal adenocarcinoma PH, polyhomeotic SCC, squamous cell carcinoma T-ALL, T-cell acute lymphoblastic leukemia TACE, TNF-α converting enzyme TKI, tyrosine kinase inhibitor VEGF, vascular endothelial growth factor XIAP, X-linked inhibitor of apoptosis protein |
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