呼吸道合胞病毒血清特异性抗体消长规律的实验研究

本文对呼吸道合胞病毒(RSV)免疫家兔后血清特异性抗体进行了动态观察。初次免疫后第四天90％家兔血清即可检出一定水平特异性Ig~M,第7—11天达峰值,于第63天完全消失。初次免疫第7天50％家免血清中出现低滴度特异性Ig~A,第35天达峰值,第147天仍有90％家兔血清存在特异性Ig~A。特异性Ig~G于初次免疫后第7天出现于80％的试验家兔血清中,第28—35天达峰值,至第147天仍全部阳性。再次免疫加强三种血清特异性抗体的反应。

EXPERIMENTAL STUDY ON THE KINETICS OFTHE SPECIFIC ANTIBODY RESPONSE TORESPIRATORY SYNCYTIAL VIRUS

The kinetics of the serum specific antibody response to primary and secondary exposure to respiraiory syncytial virus(RSV) has been studied with rabbits. The specific Ig~M began to be detecable at fourth day after first immunization, its value reached plateaus at seventh to eleventh day, then droped sharply and vanished at the sixty-third day; The specific Ig~G and Ig~A were measurable in blood at the seventh day, reached its peak value at thirty-fifth day and remained at certain level even at the 147th day after the primary immunization. The secondary immunization accelarated the specific response of all Ig~M Ig~G and Ig~A.