Ventricular somatostatin-like immunoreactivity in patients with basal ganglia disease |
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Authors: | H. Cramer A. Wolf K. Rissler K. Weigel C. Ostertag |
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Affiliation: | (1) Department of Neurology and Clinical Neurophysiology, University of Freiburg, Hansastr. 9, D-7800 Freiburg, Germany;(2) Department of Stereotaxy and Neuronuclear Medicine, University of Freiburg, Hansastr. 9, D-7800 Freiburg, Germany |
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Abstract: | Summary The concentrations of somatostatin-like immunoreactivity (SLI) in lateral ventricular fluid of patients with extrapyramidal motor disease were determined by specific radio-immunoassay. Mean SLI levels were significantly lower in patients with Parkinson's disease (mean ± SEM); 42.9±2.9 fmol/ml) and in patients with dystonic syndromes (39.4±3.2) than in patients with benign essential tremor (65.3±9.7). The lowest levels were found in patients with athetosis (34.7±5.4). In parkinsonian patients somatostatin levels correlated with the degree of akinesia, rigidity and autonomic disturbances. |
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Keywords: | Somatostatin Cerebrospinal fluid Parkinson's disease Hyperkinesia Dystonia |
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