Contribution of the reproductive hormones to the regulation of prostaglandin F2α production by immunocompetent cells |
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Authors: | S V Shirshev Yu I Shilov N N Kevorkov |
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Institution: | (1) Laboratory of Immunology, Institute of Ecology and Genetics of Microorganisms, Urals Division of the Russian Academy of Sciences, Perm |
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Abstract: | The ability of estradiol, progesterone, and chorionic gonadotropin to influence prostaglandin F2α production by intact splenocytes of CBA mice was studied. Estradiol and progesterone similarly activated the processes of
prostaglandin F2α production. No relationship was revealed between the effect and the concentration of the hormones. Chorionic gonadotropin
activated prostaglandin production by immunocompetent cells but only when used in a concentration reflecting the peak of its
physiological secretion. Combining gonadotropin with estradiol or progesterone did not lead to any appreciable differences
in the prostaglandin-stimulating action of each hormone alone.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
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8, pp. 178–180, August, 1995
Presented by K. P. Kashkin, Member of the Russian Academy of Medical Sciences |
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Keywords: | prostaglandin F2α chorionic gonadotropin estradiol progesterone splenocytes |
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