| 脂质过氧化与突发性耳聋关系的研究 |
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| 引用本文： | 赵玉林,董民声,李晓萍. 脂质过氧化与突发性耳聋关系的研究[J]. 郑州大学学报(医学版), 1995, 0(2) |
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| 作者姓名： | 赵玉林 董民声 李晓萍 |
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| 作者单位： | 河南医科大学第一附属医院耳鼻咽喉科，河南医科大学第一附属医院药剂科 |
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| 摘 要： | 测定了５２例突发性耳聋（突聋）患者血中超氧化物歧化酶（ＳＯＤ）及丙二醛（ＭＤＡ）含量，结果显示治疗前血中ＳＯＤ含量明显下降，ＭＤＡ含量明显升高，二者与正常对照组比较，Ｐ值皆＜０．０５；治疗后血中ＳＯＤ含量恢复到接近正常水平，而ＭＤＡ含量则明显下降，与正常值比较，Ｐ＜０．０５，且听力亦明显改善。提示自由基引起的脂质过氧化与突聋发病有关。
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| 关 键 词： | 脂质过氧化；耳聋；超氧化物歧化酶；丙二醛 |
Study on the relation between lipid peroxidation (LPO) and sudden deafness |
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| Zhao Yulin, Dong Minsheng, Li Xiaoping. Study on the relation between lipid peroxidation (LPO) and sudden deafness[J]. Journal of Zhengzhou University: Med Sci, 1995, 0(2) |
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| Authors: | Zhao Yulin Dong Minsheng Li Xiaoping |
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| Abstract: | The contents of SOD and MDA were measured in the blood from fifty two patients with sudden deafness. Before treatment the results showed that the contents of SOD declined (P<0.01) and the contents of MDA rose significantly (P<0.01) as compared with the normal group.After treatment,the contents of SOD rose significantly to near the normal level again,and the contents of MDA declined significantly (P<0.05) as compared with the normal group. At the same time,the hearing of the patients had also improved obviously. The data suggested that the LPO induced by free radical might be related to the attack of sudden deafness. |
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| Keywords: | lipid peroxidation deafness sudden superoxide dismutase malondialdehyde. |
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