Guideline for diagnosis and therapy of osteoporosis from a point of view of sex difference

Osteoporosis occurs more common in women than that in men. In addition, there exist the sex differences in bone indexes such as bone mineral density (BMD), bone mineral content, and bone area or width, and in the decreased pattern of BMD associated with aging. Therefore, it is necessary to use a cut-off value of BMD of not women but men, as diagnostic criteria for male osteoporosis. In this article, from a point of view of sex difference, diagnosis and treatment of osteoporosis will be reviewed.