The effect of growth factors in fracture healing and composite grafts of growth factors and marrow mesenchymal cells

Growth factors have been reported to show important roles in fracture healing process. Many studies of experimental animal models demonstrated that some growth factors could enhance bone formation. Clinical applications using the growth factors have been reported, however, effective strategies have not been established. Here, we report a mini review of the growth factors and our new technology, which utilizes growth factors and marrow mesenchymal stem cells.