保留肾单位手术术中切缘冰冻病理与术后病理对比分析

对163例行保留肾单位手术治疗的肾细胞癌患者术中切缘快速冰冻病理检查与术后病理检查资料进行分析。患者平均年龄58岁（21—87岁），肾肿瘤平均大小2．8cm（1．0～4．0cm）。5例（3．1％）术中切缘病理为阳性，行。肾根治性切除，术后病理检查未发现肿瘤残余；158例术中病理为阴性者中，术后病理检查证实6例（3．8％）手术切缘存在肿瘤组织浸润。提示肾部分切除术的术中冰冻病理检查临床意义较小，对其应用价值应重新评估。

Limited significance of frozen section analysis in nephron sparing surgery

One hundred sixty-three cases with a mean age of 58 years (range 21 to 87) underwent nephron sparing surgery due to suspected renal tumors.Mean tumor size was 2.8 cm (range 1.0 to 4.0 cm).Frozen section analysis was routinely performed during surgery,positive tumor margins in frozen section analysis were found in 5 cases (3.1%),and immediate radical nephrectomy was followed.Among 158 cases,in which frozen section analysis showed negative margins,paraffin sections disclosed positive tumor margins in 6 cases (3.8%).Our results suggest that frozen section analysis during nephron sparing surgery has limited clinical significance and hence routine incorporation in urological practice should be reconsidered.