| rh—EPO对大鼠颅脑损伤模型脑红蛋白表达研究 |
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| 引用本文： | 雷鹏,贺建勋,张卫民. rh—EPO对大鼠颅脑损伤模型脑红蛋白表达研究[J]. 中华神经外科疾病研究杂志, 2009, 8(2): 101-104 |
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| 作者姓名： | 雷鹏 贺建勋 张卫民 |
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| 作者单位： | 兰州军区兰州总医院神经外科,全军脑肿瘤诊治中心,甘肃,兰州,730050 |
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| 摘 要： | 目的观察重组人促红细胞生成素rh—EPO对大鼠脑损伤后皮层脑红蛋白NGB表达的影响，探讨其在脑损伤后的意义。方法78只大鼠随机分为3组：假手术组6只，单纯颅脑损伤组36只，rh—EPO干预组36只。单纯颅脑损伤组与rh—EPO干预组模型分别按照3h、6h、12h、24h、48h、72h 6个时间点随机分为6个亚组，每个亚组6只大鼠，通过免疫组化及图像分析方法，观察打击区周边皮层中脑红蛋白NGB的表达。结果单纯颅脑损伤组打击周边区NGB蛋白免疫反应阳性细胞表达较假手术组增多（P〈0．01），在相应区域rh—EPO干预组明显高于前两组（P〈0．01）。结论rh—EPO可诱导增加大鼠脑损伤后脑红蛋白的表达。
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| 关 键 词： | 脑红蛋白 rh—EPO 脑损伤 |
Study of rh-EPO on NGB expression in cerebral cortex after traumatic brain injury in rats |
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| LEI Peng,HE Jianxun,ZHANG Weimin. Study of rh-EPO on NGB expression in cerebral cortex after traumatic brain injury in rats[J]. Chinese Journal of Neurosurgical Disease Research, 2009, 8(2): 101-104 |
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| Authors: | LEI Peng HE Jianxun ZHANG Weimin |
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| Affiliation: | LEI Peng,HE Jianxun,ZHANG Weimin Department of Neurosurgery,Lanzhou General Hospital of Lanzhou Command,Brain Tumor Diagnosis and Therapy Center of PLA,Lanzhou 730050,China |
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| Abstract: | Objective To observe the effects of recombinant human erythropoietin (rh-EPO) on neuroglobin (NGB) expression in cerebral cortex and explore its significance after traumatic brain injury in rats. Methods A total of 78 rats were divided into three groups:sham group (n=6),traumatic brain injury (TBI) group (n=36) and rh-EPO group (n=36). TBI group and rh-EPO group were divided into 6 subgroups respectively at 3,6,12,24,48 and 72 h post injury,with 6 rats in each group. NGB expression in the penumbra zone of t... |
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| Keywords: | rh-EPO |
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