| 黄藤中巴马汀与药根碱在大鼠体内药动学及口服生物利用度的研究 |
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| 引用本文： | 郑京玉,李国峰,何忠梅,祝洪艳,赵岩,郜玉钢,杨鹤,张连学. 黄藤中巴马汀与药根碱在大鼠体内药动学及口服生物利用度的研究[J]. 中国中药杂志, 2017, 42(14): 2773-2778 |
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| 作者姓名： | 郑京玉 李国峰 何忠梅 祝洪艳 赵岩 郜玉钢 杨鹤 张连学 |
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| 作者单位： | 吉林农业大学 中药材学院, 吉林 长春 130118;吉林省人参工程技术创新中心, 吉林 长春 130118,长春中医药大学 附属医院, 吉林 长春 130000,吉林农业大学 中药材学院, 吉林 长春 130118;吉林省人参工程技术创新中心, 吉林 长春 130118,吉林农业大学 中药材学院, 吉林 长春 130118;吉林省人参工程技术创新中心, 吉林 长春 130118,吉林农业大学 中药材学院, 吉林 长春 130118;吉林省人参工程技术创新中心, 吉林 长春 130118,吉林农业大学 中药材学院, 吉林 长春 130118;吉林省人参工程技术创新中心, 吉林 长春 130118,吉林农业大学 中药材学院, 吉林 长春 130118;吉林省人参工程技术创新中心, 吉林 长春 130118,吉林农业大学 中药材学院, 吉林 长春 130118;吉林省人参工程技术创新中心, 吉林 长春 130118 |
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| 基金项目： | 国家自然科学基金项目（81473176） |
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| 摘 要： | 该文通过灌胃和尾静脉2种方式对大鼠给予黄藤总生物碱,采用RP-HPLC测定大鼠血浆中巴马汀与药根碱的浓度变化后,通过3P97软件计算巴马汀与药根碱的药代动力学参数和口服生物利用度。大鼠经灌胃与尾静脉2种方式给予黄藤总生物碱60 mg·kg~(-1)后,测得的主要药代动力学参数如下:灌胃给药组中巴马汀和药根碱的Cmax分别为(0.91±0.06),(0.70±0.08)mg·L~(-1),tmax分别为(35.24±0.83),(47.76±1.24)min,t1/2分别为(187.03±1.53),(105.64±16.99)min,AUC分别为(280.30±18.69),(144.36±1.06)mg·min·L~(-1);静脉注射给药组中巴马汀和药根碱的t1/2分别为(172.18±12.38),(147.26±1.82)min,AUC分别为(2 553.14±214.91),(328.83±10.81)mg·min·L~(-1)。巴马汀的口服生物利用度为10.98%,药根碱的口服生物利用度为43.90%。
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| 关 键 词： | 黄藤总生物碱 巴马汀 药根碱 药代动力学 口服生物利用度 RP-HPLC |
| 收稿时间： | 2017-03-17 |
Pharmacokinetics and oral bioavailability of palmatine and jatrorrhizine in Huangteng in rats |
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| ZHENG Jing-yu,LI Guo-feng,HE Zhong-mei,ZHU Hong-yan,ZHAO Yan,GAO Yu-gang,YANG He and ZHANG Lian-xue. Pharmacokinetics and oral bioavailability of palmatine and jatrorrhizine in Huangteng in rats[J]. China Journal of Chinese Materia Medica, 2017, 42(14): 2773-2778 |
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| Authors: | ZHENG Jing-yu LI Guo-feng HE Zhong-mei ZHU Hong-yan ZHAO Yan GAO Yu-gang YANG He ZHANG Lian-xue |
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| Affiliation: | College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China;Technology Innovation center of Jilin Ginseng Project, Changchun 130118, China,Changchun University of Traditional Chinese Medicine Affiliated Hospital, Changchun 130000, China,College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China;Technology Innovation center of Jilin Ginseng Project, Changchun 130118, China,College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China;Technology Innovation center of Jilin Ginseng Project, Changchun 130118, China,College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China;Technology Innovation center of Jilin Ginseng Project, Changchun 130118, China,College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China;Technology Innovation center of Jilin Ginseng Project, Changchun 130118, China,College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China;Technology Innovation center of Jilin Ginseng Project, Changchun 130118, China and College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China;Technology Innovation center of Jilin Ginseng Project, Changchun 130118, China |
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| Abstract: | In this study, the total alkaloids of Huangteng were given to the rats by the methods of intragastric administration and tail vein. After the concentration changes of palmatine and jatrorrhizine in the plasma of rats were determined by RP-HPLC, pharmacokinetic parameters and oral bioavailability were calculated by 3P97 software. After the rats were pre-treated with total alkaloid 60 mg·kg-1by the methods of intragastric administration and tail vein, the main pharmacokinetic parameters were determined as follows: in the intragastric administration group, the Cmax of palmatine and jatrorrhizine were (0.91±0.06), (0.70±0.08) mg·L-1; tmax of palmatine and jatrorrhizine were (35.24±0.83), (47.76±1.24) min; t1/2 of palmatine and jatrorrhizine were (187.03±1.53), (105.64±16.99) min, AUC of palmatine and jatrorrhizine were (280.30±18.69), (144.36±1.06) mg·min·L-1; in the intravenous injection group, the t1/2 of palmatine and jatrorrhizine were (172.18±12.38), (147.26±1.82) min; AUC of palmatine and jatrorrhizine were (2 553.14±214.91), (328.83±10.81) mg·min·L-1. The oral bioavailability of palmatine was 10.98% and jatrorrhizine was 43.90%. |
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| Keywords: | total alkaloids of Huangteng palmatine jatrorrhizine pharmacokinetics oral bioavailability RP-HPLC |
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