参麦注射液对胃癌化疗后免疫功能影响的观察

６３例胃癌患者随机分组观察，结果提示，化疗结合参麦注射液组（简称参麦组）Ｔ淋巴细胞计数（ＡＮＡＥ）上升（Ｐ＜０．０５），化疗组（简称对照组）ＡＮＡＥ下降（Ｐ＜０．０５）；化疗后两组ＯＫＴ１值、ＯＫＴ４／ＯＫＴ８值均有下降，动态结果提示参麦组上述指标提前回升，第４周明显高于化疗前水平（Ｐ＜０．０５），对照组第４周仍处于较低水平；化疗后参麦组血清可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）水平下降（Ｐ＜０．０５），ＮＫ、ＬＡＫ水平上升（Ｐ＜０．０５）；对照组ｓＩＬ－２Ｒ水平无明显变化（Ｐ＞０．０５），ＮＫ、ＬＡＫ水平下降（Ｐ＜０．０５）；两组化疗前后ＩｇＡ、ＩｇＭ、ＩｇＧ水平无明显变化（ｐ＞０．０５）。表明参麦注射液可改善患者免疫功能，有助于化疗的施行。

Effects of Shenmai Injection on Immune Function in Stomach Cancer Patients after Chemotherapy

Sixty-three cases with stomach cancer were randomized and observed, the results showed that the count of T lymphocytes in chemotherapy combined with Shenmai injection (SMI) group increased,while in control group it decreased,the difference was significant(P<0.05).The results also indicated that the count of OKT4 cells and the ratio of OKT4/OKT8 decreased after chemotherapy,but in SMI group both parameters increased in advence which were higher in the 4th week after chemotherapy than that before chemotherapy.However,the count of OKT1 cells and the ratio of OKT4/OKT8 were still in low level.Serum interleukin-2 receptor(sIL-2R) level also decreased (P<0.005),while activities of natural killer cell(NK) and lymphokine activated killer cell(LAK) level increased(P<0.05) in SMI group.Although the sIL-2R level had no change,both NK and LAK level decreased in control group.In addition,the difference of IgA,IgM,IgG level were not significant between these two groups.This suggested that SMI might improve human immune function to facilitate the chemotherapy of patients with stomach cancer.