Affiliation: | (1) Otsuka GEN Research Institute, Otsuka Pharmaceutical Co., Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima 771-0192, Japan Tel. +81-88-665-2888; Fax +81-88-637-1035 e-mail: atanigam@otsuka.gr.jp, JP;(2) First Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan, JP;(3) Ako Research Institute, Otsuka Pharmaceutical Co., Ltd., Hyogo, Japan, JP;(4) Department of Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima, Japan, JP |