| IL-7及其受体在T淋巴细胞发育中的作用及对运动免疫的意义 |
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| 引用本文： | 张琳,郝选明,邓树勋,肖鹏.IL-7及其受体在T淋巴细胞发育中的作用及对运动免疫的意义[J].国际免疫学杂志,2010,33(4):442-445. |
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| 作者姓名： | 张琳 郝选明 邓树勋 肖鹏 |
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| 作者单位： | 华南师范大学生命科学学院,广州,510631;华南师范大学体育科学学院,广州,510631; |
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| 摘 要： | 运动训练显著影响机体的免疫功能,T淋巴细胞亚群的平衡是维持免疫系统内部环境稳定的一个中心环节.IL-7/IL-7受体(IL-7R)在促进淋巴细胞,尤其是T淋巴细胞产生、分化和发育成熟的过程中发挥重要作用.从了解IL-7/IL-7 R的生物学特性、信号通路及其在T细胞发育、生存、扩增和记忆性T细胞发育中的重要作用,从细胞免疫产生的源头来分析IL-7/IL-7R运动影响免疫功能的机理,可为改善机体免疫功能提供新的思路.
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| 关 键 词： | IL-7受体 T淋巴细胞发育 运动免疫 |
The function of interleukin-7/interleukin-7 receptor during T lymphocytes development and the significance in exercise immunity |
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| ZHANG Lin,HAO Xuan-ming,DENG Shu-xun,XIAO Peng.The function of interleukin-7/interleukin-7 receptor during T lymphocytes development and the significance in exercise immunity[J].International Journal of Immunology,2010,33(4):442-445. |
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| Authors: | ZHANG Lin HAO Xuan-ming DENG Shu-xun XIAO Peng |
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| Abstract: | Exercise influences immune function significantly. The balance between T lymphocyte subsets is critical importance for the stability of immune system. IL-7/IL-7R are essential for lymphocyte proliferation, development and maturation, especially for T lymphocyte. This paper reviews the biological characters of IL-7 and its receptor (IL-7R). Their importance in the development, peripheral survival, and expansion of Tcells are also summarized. |
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| Keywords: | IL-7Interleukin-7Interleukin-7 receptorT lympholeukocyte developmentExercise immunity |
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