| 受体结合实验及其在放射性显像剂研究中的应用进展 |
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| 引用本文： | 周雪,乔晋萍,孔爱英,朱霖.受体结合实验及其在放射性显像剂研究中的应用进展[J].国际放射医学核医学杂志,2010,34(2):321-325. |
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| 作者姓名： | 周雪 乔晋萍 孔爱英 朱霖 |
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| 作者单位： | 北京师范大学化学学院放射性药物教育部重点实验室,100875;总后卫生部药品仪器检验所,北京,100071; |
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| 基金项目： | 国家重点基础研究发展规划(973计划)国家高技术研究发展计划(863计划) |
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| 摘 要： | 受体结合实验是一种重要的药物筛选方法,它通过体外实验来考察配体与受体的结合能力.目前,很多放射性显像剂是利用放射性配体与体内受体结合的高度选择性来进行受体显像的.因此,受体结合实验是放射性显像剂研究中广泛使用的一种体外评价方法,在放射性显像剂设计与筛选中发挥了重要作用.
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| 关 键 词： | 放射性药物 药物设计 受体结合实验 放射配体测定 |
Progress on the application of ligand receptor binding assays in radiopharmaceuticals |
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| ZHOU Xue,QIAO Jin-ping,KONG Ai-ying,ZHU Lin.Progress on the application of ligand receptor binding assays in radiopharmaceuticals[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(2):321-325. |
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| Authors: | ZHOU Xue QIAO Jin-ping KONG Ai-ying ZHU Lin |
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| Abstract: | Receptor binding assay is an important drug screening method, which can quickly and inexpensively study the interactions between the targeted receptor and the potential ligands in vitro and provide the information of the relative binding affinity of ligand-receptor. The imaging of many radiopharmaceuticals is based on highly selective radioligand-receptor binding. The technique plays an important role in the design and screening of receptor-targeting radiopharmaceuticals. |
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| Keywords: | RadiopharmaceuticalsDrug designLigand receptor binding assayRadioligand assay |
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