晚期非小细胞肺癌患者化疗前后血清乳酸脱氢酶水平变化及其意义

目的 探讨晚期非小细胞肺癌患者化疗前后血清乳酸脱氢酶(LDH)水平的变化及其与化疗疗效和疾病进展的关系.方法 57例晚期非小细胞肺癌患者接受标准一线化疗方案,部分患者接受二线化疗方案治疗,根据化疗前后肺部CT影像学改变进行分析,同时监测化疗过程中血清LDH水平的变化,分析血清LDH水平的变化及其与化疗疗效和疾病进展的关系.结果 肺癌患者血清LDH水平显著高于正常健康志愿者;一线方案化疗有效者LDH水平较化疗前降低(P＜0.05),而一线方案化疗失败患者LDH水平较化疗前升高(P＜0.01);肿瘤复发时和疾病控制期相比LDH显著升高(P＜0.01);疾病进展患者经二线化疗方案治疗有效组LDH水平较化疗前降低(P＜0.05),在二线化疗失败组LDH水平较化疗前明显升高(P＜0.05).结论 血清中LDH水平变化可反映肺癌化疗疗效,且可用于监测肺癌复发.

Lactate dehydrogenase level in serum of patients with advanced non-small cell lung cancer before and after chemotherapy and its significance

Objective To investigate lactate dehydrogenase (LDH) level in serum of patients with advanced non-small cell lung cancer (NSCLC) before and after chemotherapy and the relationship of it with efficacy of chemotherapy and disease progression. Methods 57 patients with advanced NSCLC received standard first-line chemotherapy and some patients received second-line chemotherapy. The lung CT imaging changes were observed before and after chemotherapy. The serum LDH level was monitored during chemotherapy. The changes of serum LDH level and its relationship with efficacy of chemotherapy and disease progression were analyzed. Results The serum LDH level in patients with NSCLC was significantly higher than that in the normal. After first-line chemotherapy, the remissive group showed decreased LDH level, and the progressive group showed increased LDH level. LDH level in tumor recurrence was significantly higher than that in remissive period. After second-line chemotherapy for the progressive patients, the remissive group also showed decreased LDH level, and the progressive group showed increased LDH level. Conclusions Serum LDH level may reflect chemotherapy efficacy of lung cancer,and can be used to monitor recurrence of lung cancer.