| PI3K/Akt通路阻断在恶性肿瘤治疗中的研究进展 |
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| 引用本文： | 王春茂,王鸿程. PI3K/Akt通路阻断在恶性肿瘤治疗中的研究进展[J]. 国际呼吸杂志, 2010, 31(23): 785-787. DOI: 10.3760/cma.j.issn.1673-436X.2011.010.014 |
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| 作者姓名： | 王春茂 王鸿程 |
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| 作者单位： | 泸州医学院附属医院呼吸内科,646000; |
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| 摘 要： | 在肺癌的发生发展过程中,常伴有PI3K/Akt信号通路的异常活化,过度激活后,可导致一系列反应,包括肿瘤牛长、血管生成、增殖和转移.本文拟就PI3K/Akt信号通路的组成与功能、调节、抗肿瘤细胞凋亡以及治疗等方面的研究进展作一综述,并就其通路的阻断作用在肺癌治疗中的应用作介绍,期待以PI3K/Akt信号通路中关键分子为靶点对肺癌治疗研究提供参考.
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| 关 键 词： | 信号转导 恶性肿瘤 靶向治疗 |
Research progress of blocking PI3K/Akt pathway in treatment of malignant tumor |
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| WANG Chun-mao,WANG Hong-cheng. Research progress of blocking PI3K/Akt pathway in treatment of malignant tumor[J]. International Journal of Respiration, 2010, 31(23): 785-787. DOI: 10.3760/cma.j.issn.1673-436X.2011.010.014 |
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| Authors: | WANG Chun-mao WANG Hong-cheng |
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| Abstract: | In the development of lung cancer. PI3K/Akt signal pathway is often abnormally activated. Its excessive activation can lead to a series of reactions,including tumor growth,angiogenesis,proliferation and metastasis. This article reviews recent progress on the composition,function of PI3K/ Akt signal pathway,regulation,anti-tumor cell apoptosis and therapy,and the application of blocking PI3K/Akt pathway in the treatment of lung cancer,which provide reference for the treatment of lung cancer using key molecules of PI3K/Akt signal pathway as a target. |
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| Keywords: | PI3k/AktPI3K/AktSignal transductionMalignant tumorTargeted therapy |
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