基因芯片技术及其在寄生虫学研究中的应用

随着人类基因组计划(human genome project,HGP)和一些模式生物基因组计划的完成,基因序列数据正以前所未有的速度迅速增长,对基因组学的研究已从结构基因组学逐步转向了功能基因组学.由于基因芯片技术操作简便,获得的信息高度特异、稳定,在寄生虫学研究领域已得到广泛应用.随着寄生虫分子遗传学研究的进展和寄生虫基因芯片检测工具的开发应用,这一技术用于筛选寄生虫功能基因,探索寄生虫与宿主相互作用,研究寄生虫发病机制及筛选寄生虫诊断抗原、药物靶标和疫苗分子等,大大推动了寄生虫学领域的研究进程.该文主要介绍了基因芯片技术的分类,并就近几年来基因芯片技术在寄生虫学研究方面的应用作一综述.

Gene chip technology and its application in parasitology research

With the completion of human genome project(HGP) and a number of model organism genome project,gene sequence data are rapidly growing at an unprecedented rate,the research on genomics has gradually shifted from structural genomics to functional genomics. As gene chip technology is simple,highly specific information available and stable,it has been widely used in the field of parasitology. With the progress in molecular genetics of parasites and the development and application of parasite gene chip detection tool,this technology has been used for screening parasite genes to explore the interaction between parasite and host,to study the pathogenesis and to screen parasite diagnostic antigens,drug targets and vaccine molecules,so as to greatly promote the pace of research in the field of parasitology. This paper described the classification of gene chip,and reviewed the latest progress of gene chip technology in the parasitology research.