CD44s和CD15在前列腺癌组织中的表达及其意义

Objectives To investigate expression of cell adhesion molecule CD44 sand CD15 in prostate carcinoma(PCa), and to evaluate its clinical significance. Methods Forty two cases of PCa and 15 of benign prostate hyperplasia(BPH) were detected by immunolhistochemical technique and the intensity of CD44s and CD15 expression was assessed by computer image analysis system. Results (1) The intensity of CD44s expression was significantly lower in PCa than that in BPH. PCa showed significant loss of CD44s expression, which correlated with the rise of tumor Gleason grade and clinical stage( p＜0.01 ), The intensity of CD44s expression was significantly lower inmetastasis group than that in nonmetastasis group( p ＜ 0.01 ). (2)The intensity of CD15 expression was significantly higher in PCa than that in BPH. The upregnlation of the CD15 correlated with the rise of tumor Gleason grade and clinical stage( p＜0.01 ). The intensity of CD15 expression was significantly higher in metastasis group than in nonmetastasis group. (3)There was significant reverse correlation between the expression level of CD44s and CD15 (r = -0.785, p＜0.001). Conclusions Aberrant expressions of CD44s and CD15 may be correlated with clinical stage, Gleason grade and metastasis in PCa. CD44s and CD15 play an important role in the malignant progression of PCa, and could be used as a marker of malignant potention and prognosis of patient with PCa.

Quantitative Analysis of CD44Sand CD15 in Prostate Carcinoma and Its Clinical Significance