Act1作用的分子机制及其与免疫损伤性疾病关系的研究进展

T and B cell-mediated immune responses play a critical role in the control and modulation of autoimmune diseases. NF-kappa B Activator 1 (Act1) , also called (connection to Iκ B kinase and stress-activated protein kinases,CIKS), is a recently identified molecule, which activates NF-κB . Recent studies have shown that Act1 is a key positive regulator of IL-17 signaling pathway ,and an important negative regulator of B cell-mediated humeral immune responses through its function in CD40L and BAFF signaling. Act1 is critical for TH17 and B cell mediated autoimmune and inflammatory responses. Moreover, Actl may play important roles in ontogenesis. Such seemingly opposite functions of Act1 in CD40-BAFFR and IL-17R signaling are orchestrated by different domains in Act1. Such delicate regulatory mechanisms may provide a common vehicle to promote balance between host defense to pathogens and tolerance to self.

Progress in researches of molecular mechanism of Act1 and its role in autoimmune diseases