三维适形放疗联合多烯紫杉醇治疗局部晚期非小细胞肺癌近期疗效观察

目的:观察三维适形放疗联合多烯紫杉醇治疗局部晚期非小细胞肺癌的近期疗效。方法:83例局部晚期非小细胞肺癌患者(Ⅲa期或Ⅲb期)随机分为治疗组与对照组。对照组仅行三维适形放疗,治疗组给予三维适形放疗联合多烯紫杉醇治疗。结果:治疗组与对照组有效率分别为88.37%、62.50%(P<0.05);治疗组白细胞下降的发生率高于对照组(P<0.05),但予以粒细胞集落刺激因子或巨噬细胞粒细胞集落刺激因子后,均可完成治疗。结论:三维适形放疗联合多烯紫杉醇治疗局部晚期非小细胞肺癌近期疗效好。

Observation on Short-term Curative Effects of 3-dimensional Conformal Radiotherapy Combined with Taxotere on Locally Advanced Non-small Cell Lung Cancer

OBJECTIVE:To observe the short-term curative effects of 3-dimensional conformal radiotherapy(3DCRT) combined with taxotere on locally advanced non-small cell lung cancer.METHODS:83 patients Ⅲ a or Ⅲ b with locally advanced non-small cell lung cancer were divided randomly into the treatment and control group.The treatment group were treated with 3DCRT in combination with taxotere,while the control group were treated with single 3DCRT.RESULTS:The effective rates in the treatment and control group were 88.37% and 62.50%(P<0.05),respectively.The incidence of leukocyte decrease was higher in the treatment group than that in the control group(P<0.05),but the treatment was completed after the administration of granulocyte colony-stimulating factor or macrophage colony-stimulating factor.CONCLUSION:Short-term curative effects of 3DCRT combined with taxotere on locally advanced non-small cell lung cancer are found to be good.