罗库溴铵用于梗阻性肝胆疾病小婴儿的肌松效应

目的 研究单次插管剂量罗库溴铵对梗阻性肝胆疾病小婴儿的肌松效应.方法 年龄1～4个月,无神经肌肉疾病、肾功能正常的小婴儿30例均分为肝胆疾病组(A组)和无肝胆疾病对照组(B组).两组均以丙泊酚2 mg/kg、芬太尼3 μg/kg诱导,继以罗库溴铵0.6 mg/kg单次剂量静脉注射.加速度仪监测拇内收肌的单刺激收缩反应,观察其起效时间、无反应时间、临床时效和恢复指数.结果 A组起效时间为(81±35)s,长于B组的(51±28)s(P<0.05);两组无反应时间、临床时效、恢复指数差异无统计学意义.结论 在梗阻性肝胆疾病婴幼儿,罗库溴铵起效时间延长.

Pharmacodynamics of rocuronium in infants with obstructive jaundice

Objective To investigate the pharmacodynamics of rocuronium in infants with obstructive jaundice.Methods Thirty infants aged 1 to 4 months without neuromuscular diseases or renal dysfunction were divided into two groups with 15 cases each.The patients in group A were diagnosed with biliary atresia and scheduled for the kasai operation,and those in group B were with normal liver function and scheduled for abdominal surgery as the controls.Anestheisa was induced with propofol 2 mg/kg and fentanyl 3 g/kg.Rocur...