| 3种他汀类药物抗炎作用的实验研究 |
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| 引用本文： | 赵征,王炎焱,黄烽,任建平.3种他汀类药物抗炎作用的实验研究[J].中国新药杂志,2005,14(12):1421-1423. |
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| 作者姓名： | 赵征 王炎焱 黄烽 任建平 |
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| 作者单位： | 1. 解放军总医院风湿科,北京,100853
2. 军事医学科学院放射医学研究所,北京,100850 |
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| 摘 要： | 目的:研究3种他汀类药物的抗炎作用.方法:急性抗炎模型采用巴豆油致小鼠耳肿胀模型和角叉菜胶致大鼠足肿胀模型,慢性抗炎模型采用棉球植入小鼠腹腔致肉芽肿模型.以布洛芬作为阳性对照,观察洛伐他汀、辛伐他汀和普伐他汀的抗炎作用.结果:他汀类药物对巴豆油致小鼠耳肿胀、角叉菜胶致大鼠足肿胀和棉球致小鼠腹腔肉芽肿形成均有显著的抑制作用.结论:他汀类药物具有显著的抗炎作用.
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| 关 键 词： | 洛伐他汀 辛伐他汀 普伐他汀 抗炎作用 |
| 文章编号： | 1003-3734（2005）12-1421-03 |
| 修稿时间： | 2005-05-31 |
Anti-inflammatory effect of three statin agents |
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| ZHAO Zheng,WANG Yan-yan,HUANG Feng,REN Jian-ping.Anti-inflammatory effect of three statin agents[J].Chinese Journal of New Drugs,2005,14(12):1421-1423. |
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| Authors: | ZHAO Zheng WANG Yan-yan HUANG Feng REN Jian-ping |
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| Institution: | 1 Department of Rheumatology, Chinese PLA General Hospital, Beijing 100853, China ; 2 Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China |
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| Abstract: | To evaluate the anti-inflammatory activity of 3 statin agents.Methods:An acute inflammatory reaction model employing croton oil as inflammagen to induce mouse ear edema and carrageenan as inflammagen to induce rat paw swelling,and a chronic inflammatory reaction model placing cottons into abdominal cavity of rats to induce granuloma were set up to test anti-inflammatory activity of lovastatin,simvastatin and pravastatin.Results:Statins showed significant inhibitions of inflammatory activities in all models.Conclusion:Statins are effective drugs against inflammation. |
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| Keywords: | lovastatin simvastatin pravastatin anti-inflammatory activity |
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